4'-epi-doxorubicin and hyperthermia in a murine mammary carcinoma: Influence of the dose and fractionation

A. Cividalli, D. Tirindelli Danesi, P. Altavista, M. Bonanni, D. Persiani, L. Segre, G. Cruciani

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Abstract

Our aim was to analyse the dose-response rate of 4'-epi-doxorubicin (EP) alone and EP combined with hyperthermia (HT) treatments in tumor-bearing mice. A spontaneous mammary carcinoma, transplanted into the right foot of female hybrid (C3H/RIxDBA/2J) mice, was used. EP (from 5 to 30 mg/kg) was administered i.p. and local HT (45-60 minutes at 42 or 43°C) was carried out. Mice were treated with EP and/or HT in 1, 2 or 3 doses at 8 day intervals; in the case of 3 HT treatments EP was administered before the first or before each HT session (same EP total dose). When EP was given alone, in 1 or 2 fractions: results showed a clear dose-response relationship: tumor growth delay depended on the total dose only. Combining different EP single doses and 1 HT treatment (43°C), an additive effect and perhaps a synergistic effect at the highest doses was observed. Among all tested combinations, the best results were observed combining 3 HT with only 1 EP treatment.
Original languageEnglish
Pages (from-to)739 - 743
Number of pages5
JournalAnticancer Research
Volume15
Issue number3
Publication statusPublished - 1995
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Cividalli, A., Tirindelli Danesi, D., Altavista, P., Bonanni, M., Persiani, D., Segre, L., & Cruciani, G. (1995). 4'-epi-doxorubicin and hyperthermia in a murine mammary carcinoma: Influence of the dose and fractionation. Anticancer Research, 15(3), 739 - 743.