A biodistribution study of two differently shaped plant virus nanoparticles reveals new peculiar traits

Chiara Lico, Paola Giardullo, Mariateresa Mancuso, Eugenio Benvenuto, Luca Santi, Selene Baschieri

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Self-assembling plant virus nanoparticles (pVNPs) have started to be explored as nanometre-sized objects for biomedical applications, such as vaccine or drug delivery and imaging. Plant VNPs may be ideal tools in terms of biocompatibility and biodegradability endowed with a wide diversity of symmetries and dimensions, easy chemical/biological engineering, and rapid production in plants. Recently, we defined that icosahedral Tomato bushy stunt virus (TBSV) and filamentous Potato virus X (PVX) are neither toxic nor teratogenic. We report here the results of an interdisciplinary study aimed to define for the first time the biodistribution of unlabelled, unpegylated, underivatized TBSV and PVX by proved detecting antibodies. These data add new insights on the in vivo behaviour of these nano-objects and demonstrate that the pVNPs under scrutiny are each intrinsically endowed with peculiar properties foreshadowing different applications in molecular medicine.
Original languageEnglish
Pages (from-to)431 - 439
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume148
DOIs
Publication statusPublished - 1 Dec 2016
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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