A Corylus avellana L. extract enhances human macrophage bactericidal response against Staphylococcus aureus by increasing the expression of anti-inflammatory and iron metabolism genes

Giulia Cappelli, Daniela Giovannini, Anna Lisa Basso, Olivia Costantina Demurtas, Gianfranco Diretto, Chiara Santi, Gabriella Girelli, Loretta Bacchetta, Francesca Mariani

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Corylus avellana L. is known for its healthy properties, and yet previous studies have not dealt with its effects on human innate response. The aim of this study is to assess if C. avellana has an immune adjuvant effect. Human macrophages were pre-treated with hazelnut liquid extract, found to be rich in phenylpropanoids, and subsequently infected with Staphylococcus aureus. Based on the intracellular bacteria CFU reduction and on the treatment doses used, the donors were divided into High-Dose and Low-Dose-Responders. Expression profile for inflammatory and Iron metabolism genes, both for Peripheral Blood Mononuclear Cells and Macrophages, highlighted that Low-Dose-Responders came from a more pronounced pro-inflammatory milieu as compared with High-Dose-Responders. Blood test results revealed that Low-Dose-Responders had higher LDL C and Triglycerides and lower HDL C. Overall, our results suggest that the effect of the extract on Macrophage immune response is influenced by the intracellular inflammatory status of the donor.
Original languageEnglish
Pages (from-to)499 - 511
Number of pages13
JournalJournal of Functional Foods
Volume45
DOIs
Publication statusPublished - 1 Jun 2018
Externally publishedYes

Fingerprint

Corylus
Corylus avellana
Staphylococcus aureus
macrophages
Anti-Inflammatory Agents
Iron
Macrophages
iron
metabolism
extracts
dosage
Genes
genes
Hematologic Tests
Blood Cells
Bacteria
hematologic tests
hazelnuts
phenylpropanoids
mononuclear leukocytes

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Cappelli, Giulia ; Giovannini, Daniela ; Basso, Anna Lisa ; Demurtas, Olivia Costantina ; Diretto, Gianfranco ; Santi, Chiara ; Girelli, Gabriella ; Bacchetta, Loretta ; Mariani, Francesca. / A Corylus avellana L. extract enhances human macrophage bactericidal response against Staphylococcus aureus by increasing the expression of anti-inflammatory and iron metabolism genes. In: Journal of Functional Foods. 2018 ; Vol. 45. pp. 499 - 511.
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A Corylus avellana L. extract enhances human macrophage bactericidal response against Staphylococcus aureus by increasing the expression of anti-inflammatory and iron metabolism genes. / Cappelli, Giulia; Giovannini, Daniela; Basso, Anna Lisa; Demurtas, Olivia Costantina; Diretto, Gianfranco; Santi, Chiara; Girelli, Gabriella; Bacchetta, Loretta; Mariani, Francesca.

In: Journal of Functional Foods, Vol. 45, 01.06.2018, p. 499 - 511.

Research output: Contribution to journalArticle

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AU - Diretto, Gianfranco

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