Advances in the medical management of paediatric IBD

Marina Aloi, Federica Nuti, Laura Stronati, Salvatore Cucchiara

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

IBD includes two classic entities, Crohn's disease and ulcerative colitis, and a third undetermined form (IBD-U), characterized by a chronic relapsing course resulting in a high rate of morbidity and impaired quality of life. Children with IBD are vulnerable in terms of growth failure, malnutrition and emotional effects. The aims of therapy have now transitioned from symptomatic control to the achievement of mucosal healing and deep remission. This type of therapy has been made possible by the advent of disease-modifying drugs, such as biologic agents, which are capable of interrupting the inflammatory cascade underlying IBD. Biologic agents are generally administered in patients who are refractory to conventional therapies. However, there is growing support that such agents could be used in the initial phases of the disease, typically in paediatric patients, to interrupt and cease the inflammatory process. Until several years ago, most therapeutic programmes in paediatric patients with IBD were borrowed from adult trials, whereas paediatric studies were often retrospective and uncontrolled. However, guidelines on therapeutic management of paediatric IBD and controlled, prospective, randomized trials including children with IBD have now been published. Here, the current knowledge concerning treatment options for children with IBD are reported. We also highlight the effectiveness and safety of new therapeutic advances in these paediatric patients.© 2014 Macmillan Publishers Limited. All rights reserved.
Original languageEnglish
Pages (from-to)99 - 108
Number of pages10
JournalNature Reviews Gastroenterology and Hepatology
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2014
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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