The age-related decline in T cell functions is generally considered to be due to changes in the responding αβ T cell populations as a result of impairment of T cell differentiation in the thymus. T cells bearing the γδ TCR are normally a minor subset of circulating T cells, but often the major T cell type among lymphocytes in epithelial tissues. In this paper we show that γδ T cells are expanded in lymph nodes of irradiated mice after syngenic bone marrow transplantation. Interestingly, these γδ T cells express mainly the V(γ)3 TCR, which is characteristic of dendritic epithelial T cells that can develop in athymic nude mice and may recognize self antigens. Since the peripheral expansion of V(γ)3 T lymphocytes is closely related to bone marrow age, these observations indicate that the age-related propensity to extrathymic development of V(γ)3+ γδ+ T lymphocytes is mainly due to stem cell dysregulation in aging. This phenomenon may contribute to T cell impairment and to the increased natural cytotoxic activity of lymphoid cells in aged mice.
All Science Journal Classification (ASJC) codes
Poccia, F., Cicconi, R., Frasca, D., Mancini, C., Colizzi, V., & Doria, G. (1998). Age-related propensity to peripheral expansion of V(γ)3+ γδ+ T lymphocytes after irradiation and bone marrow transplantation. International Immunology, 10(4), 547 - 551. https://doi.org/10.1093/intimm/10.4.547