An E7-based therapeutic vaccine protects mice against HPV16 associated cancer

Aldo Venuti, Silvia Massa, Vadim Mett, Laura Dalla Vedova, Francesca Paolini, Rosella Franconi, Vidadi Yusibov

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Plant-derived vaccines represent an attractive strategy for cancer immunotherapy due to their relative safety and cost-effectiveness. We evaluated the anti-tumour activity of a Nicotiana benthamiana produced vaccine candidate based on the non-transforming E7 protein of HPV-16 fused to β-1,3-1,4-glucanase of Clostridium thermocellum. Two doses of vaccine at two week intervals were administered to groups of C57BL/6 mice starting 3 or 6 days after challenge with tumourigenic E7-expressing TC-1* cells. Inhibition of tumour growth and increased survival was observed in both groups treated with vaccine. These data suggest the potential of plants as a platform for producing therapeutic vaccines. © 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)3395 - 3397
Number of pages3
JournalVaccine
Volume27
Issue number25-26
DOIs
Publication statusPublished - 26 May 2009
Externally publishedYes

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this