Antimicrobial activity of catechol functionalized-chitosan versus Staphylococcus epidermidis

Andrea Amato, Luisa Maria Migneco, Andrea Martinelli, Loris Pietrelli, Antonella Piozzi, Iolanda Francolini

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Protein mussel-inspired adhesive polymers, characterized by the presence of catechol groups, possess superior muco-adhesive properties and have great potentiality in wound healing. Suitable materials for wound dressing should properly combine muco-adhesiveness and antimicrobial activity. In this work, catechol-functionalized chitosan was obtained by reaction with hydrocaffeic acid (HCAF), in order to investigate how catechol introduction at different content could affect the intrinsic antimicrobial activity of the polymer itself. Unexpectedly, an enhancement of chitosan antimicrobial activity was observed after catechol functionalization, with a fourfold reduction in the polymer minimum inhibitory concentration versus Staphylococcus epidermidis. Additionally, a commercial wound dressing coated with one of the synthesized CS-HCAF derivatives showed a significant reduction in the adhesion of S. epidermidis compared to the uncoated dressing (3-log reduction). The CS-HCAF derivatives also showed an interesting antioxidant property (EC50ranging from 20 to 60 μg/mL), which further confirms the potentiality of these materials as wound dressings.
Original languageEnglish
Pages (from-to)273 - 281
Number of pages9
JournalCarbohydrate Polymers
Volume179
DOIs
Publication statusPublished - 1 Jan 2018
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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