Asbestos-related lung cancer mortality in Piedmont, Italy

Marco Martuzzi, Pietro Comba, Marco De Santis, Ivano Iavarone, Maurizio Di Paola, Marina Mastrantonio, Roberta Pirastu

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Abstract

This study investigates the association between pleural neoplasm mortality, a possible proxy for asbestos exposure, and lung cancer mortality among males resident in Piedmont (northwestern Italy). Pleural neoplasm mortality was estimated in the 1,209 municipalities of the region for the period 1980-1992, applying Bayesian methods. The association with lung cancer mortality for municipalities was studied using Poisson regression. Urban/rural indicators and altitude were also included in the analysis. A positive, statistically significant association was found between pleural neoplasm and lung cancer mortality (β = 0.025, P < 0.001); lung cancer risk was associated also with urban status (vs. rural, β = 0.223, P < 0.001) and altitude (P = 0.01). The proportion of lung cancer deaths attributable to living in municipalities with increased pleural neoplasm mortality was 3.9% (95% confidence interval, 2.1-5.7%). The observed association and the presence of a dose-response relationship at the municipality level underscore the dangers of asbestos for human health.
Original languageEnglish
Pages (from-to)565 - 570
Number of pages6
JournalAmerican Journal of Industrial Medicine
Volume33
Issue number6
DOIs
Publication statusPublished - Jun 1998
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

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