Association between exposure to persistent organohalogen pollutants and epididymal and accessory sex gland function: Multicentre study in Inuit and European populations

Saad Elzanaty, Anna Rignell-Hydbom, Bo A.G. Jönsson, Henning S. Pedersen, Jan K. Ludwicki, Maryna Shevets, Valentyna Zvyezday, Gunnar Toft, Jens Peter Bonde, Lars Rylander, Lars Hagmar, Ewa Bonefeld-Jorgensen, Marcello Spano, Davide Bizzaro, Gian-Carlo Manicardi, Aleksander Giwercman

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Abstract

Exposure to persistent organochlorine pollutants (POPs) may have negative impact on male reproductive function. We, therefore, investigated the association between serum levels of POPs and epididymal and accessory sex gland function. Serum levels of CB-153, p,p′-DDE and seminal markers of epididymal [neutral-α glucosidase (NAG)], prostatic [prostate specific-antigen (PSA)] and zinc, and seminal vesicle function (fructose) were measured from 135 Swedish fishermen and fertile men from Greenland (n = 163), Warsaw, Poland (n = 167) and Kharkiv, Ukraine (n = 158). Multiple linear regression analyses, adjusting for potential confounders, were employed using both continuous and categorized exposure variables. Both exposure and outcome variables were log transformed. Considering the consistency between models with either continuous or categorized CB-153 levels, negative associations with the activity of NAG were found among Greenlandic men (mean difference 7.0 mU/ejaculate, 95% CI 3.0, 34), and in the aggregated cohort (mean difference 4.0 mU/ejaculate, 95% CI -0.2, 8.0). A positive association was observed between CB-153 and PSA as well as zinc among Kharkiv men. In the Swedish cohort, a negative association was found between CB-153 and fructose. In conclusion, the negative effects of POP on sperm motility, observed in the same study population might partly be caused by post-testicular mechanisms, involving a decreased epididymal function. © 2006 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)765 - 773
Number of pages9
JournalReproductive Toxicology
Volume22
Issue number4
DOIs
Publication statusPublished - Nov 2006
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Toxicology

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