Cancer metabolism and the dynamics of metastasis

G. Dattoli, C. Guiot, P.P. Delsanto, P.L. Ottaviani, S. Pagnutti, T.S. Deisboeck

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11 Citations (Scopus)


Cancer growth dynamics, commonly simulated with a Gompertzian model, is analyzed in the framework of a more recent and realistic model. In particular, we consider the setting of a tumor embedded in a host organ and investigate their interaction. We assume that, at least in some cases, tumor metastasis may be triggered by an 'energetic crisis', when the tumor exceeds the 'carrying capacity' of the host organ. As a consequence, dissemination of clusters of cancer cells is set in motion, with a statistical probability given by a Poisson distribution. The model, although still at a preclinical level, is fully quantitative and is applied, as an example, to the case of prostate cancer. The results confirm that, at least for the more aggressive cancers, metastasis starts very early during tumorigenesis and a quantitative link is found between the tumor's doubling time, its 'aggressiveness' and the metastatic potential. © 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)305 - 310
Number of pages6
JournalJournal of Theoretical Biology
Issue number3
Publication statusPublished - 7 Feb 2009
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Medicine(all)
  • Modelling and Simulation
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Dattoli, G., Guiot, C., Delsanto, P. P., Ottaviani, P. L., Pagnutti, S., & Deisboeck, T. S. (2009). Cancer metabolism and the dynamics of metastasis. Journal of Theoretical Biology, 256(3), 305 - 310.