Clinical evaluation of pixellated NaI:Tl and continuous LaBr

R. Pani, R. Pellegrini, M. Betti, G. De Vincentis, M.N. Cinti, P. Bennati, F. Vittorini, V. Casali, M. Mattioli, V. Orsolini Cencelli, F. Navarria, D. Bollini, G. Moschini, G. Iurlaro, L. Montani, F. de Notaristefani

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The principal limiting factor in the clinical acceptance of scintimammography is certainly its low sensitivity for cancers sized <1 cm, mainly due to the lack of equipment specifically designed for breast imaging. The National Institute of Nuclear Physics (INFN) has been developing a new scintillation camera based on Lanthanum tri-Bromide Cerium-doped crystal (LaBr3:Ce), that demonstrating superior imaging performances with respect to the dedicated scintillation γ-camera that was previously developed. The proposed detector consists of continuous LaBr3:Ce scintillator crystal coupled to a Hamamatsu H8500 Flat Panel PMT. One centimeter thick crystal has been chosen to increase crystal detection efficiency. In this paper, we propose a comparison and evaluation between lanthanum γ-camera and a Multi PSPMT camera, NaI(Tl) discrete pixel based, previously developed under "IMI" Italian project for technological transfer of INFN. A phantom study has been developed to test both the cameras before introducing them in clinical trials. High resolution scans produced by LaBr3:Ce camera showed higher tumor contrast with a detailed imaging of uptake area than pixellated NaI(Tl) dedicated camera. Furthermore, with the lanthanum camera, the Signal-to-Noise Ratio (SNR) value was increased for a lesion as small as 5 mm, with a consequent strong improvement in detectability. © 2006 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)475 - 479
Number of pages5
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Issue number1-2 SPEC. ISS.
Publication statusPublished - 1 Feb 2007
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Nuclear and High Energy Physics
  • Instrumentation

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