Controllable release from high-transition temperature magnetoliposomes by low-level magnetic stimulation

Romina Spera, Francesca Apollonio, Micaela Liberti, Alessandra Paffi, Caterina Merla, Rosanna Pinto, Stefania Petralito

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

High-transition temperature liposomes with embedded coated magnetite nanoparticles were prepared using the thin lipid film hydration method in order to obtain magnetoliposomes not sensitive to temperature increase (at least up to 50. °C). Accordingly, drug can be released from such magnetoliposomes using a low-level electromagnetic field as triggering agent, while no delivery would be obtained with temperature increase within the physiological acceptable range. The hypothesized release mechanism involves mechanical stress of the liposome membrane due to nanoparticles oscillations and it is investigated by means of a numerical model evaluated using multiphysics simulations. The carrier content was repetitively released by switching on and off a 20. kHz, 60. A/m magnetic field. The results indicated high reproducibility of cycle-to-cycle release induced by the magnetic-impelled motions driving to the destabilization of the bilayer rather than the liposome phase transition or the destruction of the liposome structure.
Original languageEnglish
Pages (from-to)136 - 140
Number of pages5
JournalColloids and Surfaces B: Biointerfaces
Volume131
DOIs
Publication statusPublished - 1 Jul 2015
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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