Dermatological single-session beta emitter conformational brachytherapy of non-melanocytic skin tumours

Antioco F. Sedda, Cesidio Cipriani, Annamaria Carrozzo

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

In the present paper a therapeutic option for the treatment of BasalCell Carcinoma (BCC) and Squamous Cell Carcinoma (SCC) is described. It basically consists in a superficial high dose brachytherapy, characterized by the use of a ready-to-use kit, in which a radioactive beta-emitting isotope, incorporated in a specially formulated inert, synthetic resin, is applied on the surface of BCC and SCC tumours. When the product is applied on the lesion, a beta emitter brachytherapy irradiation is performed, strictly limited to the area and depth affected by the tumour invasion. The electrons from high energy (> 1MeV) beta emitters isotopes deposit more than 90 % of the dose to the first two mm of the skin, which is the depth usually interested from tumour invasion, but spare the deeper tissues from irradiation. The therapy has been used in a large variety of BCC and SCC: tumours of very large sizes, relapsing or recurrent forms, multifocal lesions, without restriction of site, dimension, clinical or histological type, patients clinical situation, with exclusion of the lynphonode metastatic forms. More than 1200 lesions on 370 patients, with histologically, dermoscopically, or clinically confirmed diagnosis of BCC and SCC, have been treated. After a follow up of 12 - 78 months, a complete response was obtained in 98% of the treated lesions, in 89 % of the lesions after a single application, while in 11% of the patients two or three treatments were performed. A clear advantage of the proposed treatment respect to the surgery is especially evident for all the tumours located in difficult sites, on which surgery would be difficult (nose, ears, eyelids, etc.). The technique should be, in our opinion, the first choice treatment in all those patients with a high number of lesions, or with tumour relapses, in those with tumours located in particular sites, where surgery would produce functional mutilations (penis, vulva, eyelids etc.) and, finally, in older, infirm, or otherwise inoperable ones. © 2011 by Nova Science Publishers, Inc.
Original languageEnglish
Title of host publicationBrachytherapy: Types, Dosing and Side Effects
PublisherNova Science Publishers, Inc.
Publication statusPublished - Jan 2011
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Sedda, A. F., Cipriani, C., & Carrozzo, A. (2011). Dermatological single-session beta emitter conformational brachytherapy of non-melanocytic skin tumours. In Brachytherapy: Types, Dosing and Side Effects Nova Science Publishers, Inc..