DNA content differences in laboratory mouse strains determined by flow cytometry

Rosanna Capparelli, Carlo Cottone, Letizia D'Apice, Maurizio Viscardi, Lucia Colantonio, Sergio Lucretti, Domenico Iannelli

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The nuclear DNA content of seven mouse laboratory strains has been measured by flow cytometry. The differences observed between strains as well as those between sexes within the strain were all statistically significant. The highest DNA content (approximately 6.4 pg/female nucleus) was found in the Balb/c strain; the lowest (approximately 5.7 pg/male nucleus) in the C3H/he strain. The difference between sexes varied from 1.6% (in CD-1 mice) to 6.3% (in nude mice). The interest of these results is twofold. First, the mouse can now be used to study the adaptive significance of genome size variation, so far studied only in plants. Second, DNA content analysis can become a quick method for mouse strain identification.
Original languageEnglish
Pages (from-to)261 - 266
Number of pages6
Issue number3
Publication statusPublished - 1 Nov 1997
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Biophysics
  • Hematology
  • Endocrinology
  • Cell Biology

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