DNA origami structures interfaced to inorganic nanodevices

Claudia Dalmastri, Weihua Han, Stefano Vespucci, Liqian Wang, Piero Morales

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)


We describe here one way to achieve hybrid DNA–inorganic nanostructures on rigid flat insulating substrates. We report methods to prepare rectangular DNA origami and incubate them onto arrays of anchoring gold nanodots either in a static solution or in a microfluidic system. We give details on the design and lithographic methods employed to pattern usable arrays of gold nanoanchors on naturally oxidized silicon wafer chips. Scanning electron and atomic force microscopy methodological details are also given for obtaining the relevant characterizations of the immobilized and ordered DNA origami.
Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Publication statusPublished - 2018
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Cite this

Dalmastri, C., Han, W., Vespucci, S., Wang, L., & Morales, P. (2018). DNA origami structures interfaced to inorganic nanodevices. In Methods in Molecular Biology Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8582-1_18