Dose-response of X-irradiated human and equine lymphocytes

Carlo Catena, Luigi Asprea, Sergio Carta, Giuseppe Tortora, Daniela Conti, Patrizia Parasacchi, Enzo Righi

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3 Citations (Scopus)

Abstract

We have investigated and compared DNA damage and cell killing induced in human and equine lymphocytes after in vitro X-irradiation. Our data show that the cytogenetic and the lethality effects are both greater in equine lymphocytes, but that the difference is wider for lethality. The ratios between doses inducing the same effect are 1.3, 1.7 and 9.4 for the number of binucleated cells with micronuclei, micronucleus frequency in binucleated cells and DNA synthesis inhibition, respectively. The very different radiosensitivity observed for the two mammalian species encourages us to use their lymphocytes in cell radiobiology studies.
Original languageEnglish
Pages (from-to)9 - 16
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume373
Issue number1
DOIs
Publication statusPublished - 3 Jan 1997
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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