Early life exposure to 2.45GHz WiFi-like signals: Effects on development and maturation of the immune system

Manolo Sambucci, Federica Laudisi, Francesca Nasta, Rosanna Pinto, Rossella Lodato, Vanni Lopresto, Pierluigi Altavista, Carmela Marino, Claudio Pioli

Research output: Contribution to journalReview article

10 Citations (Scopus)


The development of the immune system begins during embryogenesis, continues throughout fetal life, and completes its maturation during infancy. Exposure to immune-toxic compounds at levels producing limited/transient effects in adults, results in long-lasting or permanent immune deficits when it occurs during perinatal life. Potentially harmful radiofrequency (RF) exposure has been investigated mainly in adult animals or with cells from adult subjects, with most of the studies showing no effects. Is the developing immune system more susceptible to the effects of RF exposure? To address this question, newborn mice were exposed to WiFi signals at constant specific absorption rates (SAR) of 0.08 or 4. W/kg, 2. h/day, 5 days/week, for 5 consecutive weeks, starting the day after birth. The experiments were performed with a blind procedure using sham-exposed groups as controls. No differences in body weight and development among the groups were found in mice of both sexes. For the immunological analyses, results on female and male newborn mice exposed during early post-natal life did not show any effects on all the investigated parameters with one exception: a reduced IFN-γ production in spleen cells from microwaves (MW)-exposed (SAR 4. W/kg) male (not in female) mice compared with sham-exposed mice. Altogether our findings do not support the hypothesis that early post-natal life exposure to WiFi signals induces detrimental effects on the developing immune system. © 2011 Elsevier Ltd.
Original languageEnglish
Pages (from-to)393 - 398
Number of pages6
JournalProgress in Biophysics and Molecular Biology
Issue number3
Publication statusPublished - Dec 2011
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biophysics
  • Molecular Biology

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