Effect of radiofrequency electromagnetic field exposure on in vitro models of neurodegenerative disease

Giovanna Del Vecchio, Alessandro Giuliani, Mercedes Fernandez, Pietro Mesirca, Ferdinando Bersani, Rosanna Pinto, Lucia Ardoino, Giorgio A. Lovisolo, Luciana Giardino, Laura Calzà

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In this work we tested viability, proliferation, and vulnerability of neural cells, after continuous radiofrequency (RF) electromagnetic fields exposure (global system for mobile telecommunications (GSM) modulated 900MHz signal at a specific absorption rate (SAR) of 1 W/kg and maximum duration 144 h) generated by transverse electromagnetic cells. We used two cellular systems, SN56 cholinergic for example, SN56 cholinergic cell line and rat primary cortical neurons, and well-known neurotoxic challenges, such as glutamate, 25-35AA beta-amyloid, and hydrogen peroxide. Exposure to RF did not change viability/proliferation rate of the SN56 cholinergic cells or viability of cortical neurons. Co-exposure to RF exacerbated neurotoxic effect of hydrogen peroxide in SN56, but not in primary cortical neurons, whereas no cooperative effects of RF with glutamate and 25-35AA beta-amyloid were found. These data suggest that only under particular circumstances exposure to GSM modulated, 900 MHz signal act as a co-stressor for oxidative damage of neural cells. © 2009 Wiley-Liss, Inc.
Original languageEnglish
Pages (from-to)564 - 572
Number of pages9
Issue number7
Publication statusPublished - Oct 2009
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biophysics
  • Physiology
  • Radiology Nuclear Medicine and imaging

Cite this

Del Vecchio, G., Giuliani, A., Fernandez, M., Mesirca, P., Bersani, F., Pinto, R., Ardoino, L., Lovisolo, G. A., Giardino, L., & Calzà, L. (2009). Effect of radiofrequency electromagnetic field exposure on in vitro models of neurodegenerative disease. Bioelectromagnetics, 30(7), 564 - 572. https://doi.org/10.1002/bem.20507