Enhanced production of bioactive ginsenosides from adventitious roots of Panax ginseng in bioreactor culture

G. Sivakumar, K.W. Yu, K.Y. Paek

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Panax ginseng C.A. Meyer roots are highly prized in international markets for their medicinal properties. The present study focussed on the enhanced production of the bioactive anti-cancer protopanaxatriol group of ginsenosides in adventitious roots of P. ginseng in bioreactor cultures by feeding the biogenetic precursor, squalene. HPLC-MS analysis of the saponin fraction indicated higher accumulation of the protopanaxatriol group of ginsenosides (Rg10.96 mg g-1, Rg20.09 mg g-1and Re 1.91 mg g-1DW) in 40 d-old squalene-fed adventitious roots compared to controls. The results allow predictions of the biosynthetic pathway from squalene to ginsenosides in adventitious roots.
Original languageEnglish
Pages (from-to)549 - 552
Number of pages4
JournalJournal of Horticultural Science and Biotechnology
Volume81
Issue number3
DOIs
Publication statusPublished - 2006
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Horticulture

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