Enhanced production of bioactive ginsenosides from adventitious roots of Panax ginseng in bioreactor culture

G. Sivakumar, K.W. Yu, K.Y. Paek

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15 Citations (Scopus)


Panax ginseng C.A. Meyer roots are highly prized in international markets for their medicinal properties. The present study focussed on the enhanced production of the bioactive anti-cancer protopanaxatriol group of ginsenosides in adventitious roots of P. ginseng in bioreactor cultures by feeding the biogenetic precursor, squalene. HPLC-MS analysis of the saponin fraction indicated higher accumulation of the protopanaxatriol group of ginsenosides (Rg10.96 mg g-1, Rg20.09 mg g-1and Re 1.91 mg g-1DW) in 40 d-old squalene-fed adventitious roots compared to controls. The results allow predictions of the biosynthetic pathway from squalene to ginsenosides in adventitious roots.
Original languageEnglish
Pages (from-to)549 - 552
Number of pages4
JournalJournal of Horticultural Science and Biotechnology
Issue number3
Publication statusPublished - 2006
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Genetics
  • Horticulture

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