Epidemiological, clinical, and molecular study of a cohort of Italian Parkinson disease patients: Association with glutathione-s-transferase and DNA repair gene polymorphisms

Tommaso Cornetta, Clarice Patrono, Irene Terrenato, Francesca De Nigris, Anna Rita Bentivoglio, Antonella Testa, Valentina Palma, Tommaso Poggioli, Luca Padua, Renata Cozzi

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7 Citations (Scopus)

Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative disorders whose etiology is multifactorial including both hereditary and environmental factors. Currently, pathogenic mutations in at least five genes have been implicated in familial PD generally accounting for less than 10 % of all PD cases in most populations. It has been suggested that polymorphisms in other genes such as those encoding enzymes involved in oxidative metabolism and detoxification could be involved in predisposition to PD since oxidative stress in dopaminergic neurons is thought to be of central importance in the pathogenesis of the disease. The aim of our work was to study the association of genetic polymorphisms in genes involved in oxidative metabolism and detoxification mechanism, namely GSTM1, GSTT1, GSTP1, and those involved in DNA damage repair, OGG1 and XRCC1, in an Italian cohort of sporadic PD patients. We did not detect any association between GSTT1 and GTTM1 null polymorphisms and PD, whereas the 104GSTP1 polymorphism was associated with PD in male patients but not in females. Furthermore, we detected a protective effect of wild type genotype of XRCC1 in women. © 2013 Springer Science+Business Media New York.
Original languageEnglish
Pages (from-to)673 - 680
Number of pages8
JournalCellular and Molecular Neurobiology
Volume33
Issue number5
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

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