Evaluation of in vitro and in vivo stability of the radiopharmaceutical [

S. Ridone, D. Arginelli, E. Inglese, A. Lucca, R. Matheoud, A. Miranti, M. Montalto, C. Peroni, M. Rudoni, C. Secco, S. Vallegiani, L. Vigna

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Abstract

The radiopharmaceutical [153Sm]Sm-EDTMP is administered for painful bone metastases with the standard dosage of 37 MBq/kg, without evaluation of patient individual characteristics. For a better dose estimate in vivo stability should be considered, because labelled and unlabelled samarium do not have the same metabolic pathway. We evaluated radiopharmaceutical in vitro stability, measuring the activity by beta and gamma spectrometry. Subsequently we verified in vivo stability on serial blood and urine samples. The percentage of the unlabelled radiopharmaceutical is high and, on the basis of radiochemical data as well as blood clearance and urine excretion, we calculated the main parameters for a preliminary biokinetic model. © Akadémiai Kiadó, 2009.
Original languageEnglish
Pages (from-to)287 - 291
Number of pages5
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume282
Issue number1
DOIs
Publication statusPublished - Oct 2009
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Ridone, S., Arginelli, D., Inglese, E., Lucca, A., Matheoud, R., Miranti, A., ... Vigna, L. (2009). Evaluation of in vitro and in vivo stability of the radiopharmaceutical [. Journal of Radioanalytical and Nuclear Chemistry, 282(1), 287 - 291. https://doi.org/10.1007/s10967-009-0277-2