Experimental determination of calibration settings of a commercially available radionuclide calibrator for various clinical measurement geometries and radionuclides

A. Ceccatelli, M. Benassi, M. D'Andrea, P. De Felice, A. Fazio, S. Nocentini, L. Strigari

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Following the approach of the National Primary Laboratory of the UK (NPL) for the calibration of radionuclide calibrators, but using a commercially available instrument with no data available in the literature, the radionuclide calibrator response was investigated as a function of different measurement geometries at the "Regina Elena" National Cancer Institute (IRE) in Rome. Working with Italian National Metrology Institute for ionising radiation quantities (ENEA-INMRI), specific calibration factors with traceability to national primary standards were determined for different types of glass vials, solid capsules and plastic syringes, investigating three radionuclides with different energy spectra (Tc-99 m, In-111, I-131). For each kind of syringe, calibration correction factors for different filling volumes were calculated. For Tc-99 m and I-131 the difference between measured and true activity was in the range 2-7%, depending on measurement geometry. For In-111 a large percentage deviation from the true activity value was found in each geometry considered, reaching 35%. The magnitude of this difference is particularly dependent on the energies of the emitted photons. © 2006 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)120 - 125
Number of pages6
JournalApplied Radiation and Isotopes
Issue number1
Publication statusPublished - Jan 2007
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Radiation

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