G

Tommaso Poggioli, Silvia Sterpone, Selena Palma, Renata Cozzi, Antonella Testa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Breast cancer (BC) is the most common type of malignancy in female patients and radio-treatment is the conventional therapy even if a great number of studies reported that enhanced sensitivity to ionizing radiation as measured as chromosome effects is present in a significant proportion of cancer patients, including breast cancer ones. In this study we analysed whether peripheral blood lymphocytes from sporadic BC patients and healthy subjects showed a different sensitivity to ionizing radiation and whether cytogenetic radiosensitivity may serve as a breast cancer risk biomarker. To test this hypothesis, the in vitro radiation sensitivity was measured by using both G0and G2chromosome radiosensitivity assays, on 46 subjects (23 BC patients and 23 healthy subjects). Results show that cancer patients are more radiosensitive than healthy controls and that G2assay could be more appropriate to define the individual radiosensitivity if compared to G0assay.
Original languageEnglish
Pages (from-to)615 - 619
Number of pages5
JournalJournal of Radiation Research
Volume51
Issue number5
DOIs
Publication statusPublished - 2010
Externally publishedYes

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

Cite this

Poggioli, T., Sterpone, S., Palma, S., Cozzi, R., & Testa, A. (2010). G. Journal of Radiation Research, 51(5), 615 - 619. https://doi.org/10.1269/jrr.10052