Haemopoietic reconstitution after sublethal irradiation: Comparison of the effects of different haemopoietic cytokines on murine lymphocytes and bone marrow cells

Daniela Frasca, Francesco Guidi, Paola Barattini, Gino Doria

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Abstract

Sublethally irradiated mice were injected with recombinant cytokines to stimulate haemopoietic reconstitution. Interleukin (IL)-11 and IL-6 were able to significantly accelerate the recovery of thymus, spleen and bone marrow cells when used in combination with IL-3, but not alone. Stem cell factor (SCF) also displayed detectable effects when used with IL-3. Conversely, the IL-6 superagonist K-7/D-6 was able, even when used alone, to induce recovery of thymus, spleen and bone marrow cells up to the level of unirradiated controls. Together, these results indicate that it is possible to attain complete recovery of lymphoid organs and tissues as early as 7d after irradiation by use of haemopoietic cytokines.
Original languageEnglish
Pages (from-to)317 - 324
Number of pages8
JournalBritish Journal of Haematology
Volume106
Issue number2
DOIs
Publication statusPublished - 1999
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Hematology

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