Hyaluronic Acid Nanoporous Microparticles with Long In Vivo Joint Residence Time and Sustained Release

Graziana Palmieri, Antonio Rinaldi, Luisa Campagnolo, Mariarosaria Tortora, Maria Federica Caso, Maurizio Mattei, Andrea Notargiacomo, Nicola Rosato, Massimo Bottini, Francesca Cavalieri

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A simple approach is reported to engineer biodegradable and biocompatible nanoporous hyaluronic acid particles (NPHAs) with a characteristic sponge-like morphology and uniform size. These NPHAs can be synthesized using the concomitant cross-linking of hyaluronic acid and the cross-linking agent precipitation. The nanoporous architecture of NPHAs prevents the rapid enzymatic degradation of hyaluronic acid and controls the erosion of microparticles in physiological conditions. Once injected into an intra-articular body cavity of healthy mice, these NPHAs reside at the point-of-delivery for an extended time period, exhibiting a sustained release of hyaluronic acid. In addition, in vivo studies indicate the persistence of NPHAs in the knee joints with neither accumulation into major organs, nor any local or systemic side-effect. The use of NPHAs is emphasized as reservoirs of hyaluronic acid, effectively providing an innovative and safe platform for prolonging the favorable effects displayed by hyaluronic acid on joints affected by osteoarthritis.
Original languageEnglish
Article number1600411
Pages (from-to)-
JournalParticle and Particle Systems Characterization
Issue number6
Publication statusPublished - 1 Jun 2017
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Palmieri, G., Rinaldi, A., Campagnolo, L., Tortora, M., Caso, M. F., Mattei, M., Notargiacomo, A., Rosato, N., Bottini, M., & Cavalieri, F. (2017). Hyaluronic Acid Nanoporous Microparticles with Long In Vivo Joint Residence Time and Sustained Release. Particle and Particle Systems Characterization, 34(6), -. [1600411]. https://doi.org/10.1002/ppsc.201600411