In vitro evaluation of the mutagenic and carcinogenic power of high purity zirconia ceramic

V. Covacci, N. Bruzzese, G. Maccauro, C. Andreassi, G.A. Ricci, C. Piconi, E. Marmo, W. Burger, A. Cittadini

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Tetragonal zirconia polycrystal (TZP) is a new interesting ceramic for the manufacture of medical devices. Its wide use in orthopedic and odontoiatric implants was limited till now by the high chemical and radiochemical impurities of the raw materials. Purification processes now available allow to obtain high purity ceramic grade powders suitable for TZP ceramics manufacture, even if their possible mutagenic and transforming effects are still unclear. The aim of this work is to study in vitro the mutagenic and oncogenic effects of a new zirconia ceramic stabilized by yttria (Y-TZP). This ceramic was sintered from high purity powders obtained by a process developed under a project carried out within the Brite EuRam programme. For comparison, ceramics made from unpurified zirconia powder were also tested. Fibroblasts irradiated by a linear accelerator were used as positive control. The results obtained show that Y-TZP ceramic does not elicit either mutagenic or transforming effect on C3H/10T(1/2) (10T(1/2)) cells and demonstrate that ceramic from high purity powders can be considered suitable for biomedical applications from the point of view of the effects of its radioactive impurity content.
Original languageEnglish
Pages (from-to)371 - 376
Number of pages6
Issue number4
Publication statusPublished - Feb 1999
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Covacci, V., Bruzzese, N., Maccauro, G., Andreassi, C., Ricci, G. A., Piconi, C., ... Cittadini, A. (1999). In vitro evaluation of the mutagenic and carcinogenic power of high purity zirconia ceramic. Biomaterials, 20(4), 371 - 376.