In vivo characterization of Zirconia Toughened Alumina material: A comparative animal study

G. Maccauro, A. Cittadini, G. Magnani, S. Sangiorgi, F. Muratori, P.F. Manicone, P. Rossi Iommetti, D. Marotta, A. Chierichini, Luca Raffaelli, A. Sgambato

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Abstract

The development of a new chromia-doped Zirconia Toughened Alumina (ZTA) material was previously reported as displaying mechanical properties suitable for implants with load bearing applications, such as orthopaedic and dental implants. This type of biomaterial is expected to be in contact with living tissues for a long period of time and its long-term toxicity must be carefully evaluated. In this study the suitability of this ZTA material as a candidate biomaterial for orthopaedic implants and dental devices was further investigated in vivo in comparison to alumina and zirconia, which are currently used in orthopaedic and dental surgery. Cylinders of the materials were implanted in vivo in white rabbits, and local and systemic tissue reactions were analyzed at different time intervals after surgery. Radiologic examinations displayed the absence of radiolucence around cylinders and no signs of implant loosening up to twelve months. No tumours developed in the animals either locally (at the site of implantation), or systemically in the peripheral organs. The results obtained suggest that this new ZTA material does not display any long term pathogenic effect in vivo. These findings extend our previous observations on the biocompatibility and the absence of any long-term carcinogenic effect in vitro of this material which displays interesting properties for biomedical applications. In conclusion, we report the in vivo characterization of a new chromia-doped ZTA material and confirm its suitability as a candidate biomaterial for orthopaedic implants and dental devices since it does not give any local nor systemic toxicity even after a long period of time after implantation. Copyright © by BIOLIFE, s.a.s.
Original languageEnglish
Pages (from-to)841 - 846
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Volume23
Issue number3
DOIs
Publication statusPublished - 2010
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Maccauro, G., Cittadini, A., Magnani, G., Sangiorgi, S., Muratori, F., Manicone, P. F., ... Sgambato, A. (2010). In vivo characterization of Zirconia Toughened Alumina material: A comparative animal study. International Journal of Immunopathology and Pharmacology, 23(3), 841 - 846. https://doi.org/10.1177/039463201002300319