Inhibition of both skin and lung tumorigenesis by Car-R mouse-derived cancer modifier loci

Anna Saran, Daniela Zaffaroni, Simonetta Pazzaglia, Bernard Peissel, Federica Galbiati, Monica Spinola, Giacomo Manenti, Nicola Zanesi, Simonetta Rebessi, Maria Teresa Mancuso, Vincenzo Covelli, Tommaso A. Dragani

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5 Citations (Scopus)

Abstract

The Car-R outbred mouse line was phenotypically selected for high resistance to two-stage skin tumorigenesis. In the present study we tested the hypothesis that a subset of genetic loci responsible for resistance to skin tumorigenesis of Car-R mice might also inhibit lung tumorigenesis. Skin and lung tumorigenesis were induced in groups of Car-R, SWR/J, (SWR/JxCar-R)FI and SWR/Jx(SWR/JxCar-R) backcross mice by i.p. urethane initiation and skin TPA promotion. Car-R mice showed a much lower susceptibility to both skin and lung tumorigenesis as compared to SWR/J mice, which are susceptible to both lung and skin tumorigenesis. The Car-R-inherited genome significantly inhibited both skin and lung cancer development in the FI progeny of Car-R with SWR/J mice. In the backcross population, skin and lung tumor phenotypes showed a statistically significant correlation, indicating that a subset of the cancer resistance alleles, which segregated in the Car-R line during selection for resistance to skin carcinogenesis, provides resistance to both skin and lung tumorigenesis. © 2002 Wiley-Liss, Inc.
Original languageEnglish
Pages (from-to)580 - 583
Number of pages4
JournalInternational Journal of Cancer
Volume97
Issue number5
DOIs
Publication statusPublished - 10 Feb 2002
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

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