Innovative non-animal testing strategies for reproductive toxicology: The contribution of Italian partners within the EU project ReProTect

Stefano Lorenzetti, Ilaria Altieri, Sabina Arabi, Donatella Balduzzi, Nicoletta Bechi, Eugenia Cordelli, Cesare Galli, Francesca Ietta, Silvia C. Modina, Laura Narciso, Francesca Pacchierotti, Paola Villani, Andrea Galli, Giovanna Lazzari, Alberto Maria Luciano, Luana Paulesu, Marcello Spanò, Alberto Mantovani

Research output: Contribution to journalArticle

21 Citations (Scopus)


Reproductive toxicity, with its many targets and mechanisms, is a complex area of toxicology; thus, the screening and identification of reproductive toxicants is a main scientific challenge for the safety assessment of chemicals, including the European Regulation on Chemicals (REACH). Regulatory agencies recommend the implementation of the 3Rs principle (refinement, reduction, replacement) as well as of intelligent testing strategies, through the development of in vitro methods and the use of mechanistic information in the hazard identification and characterization steps of the risk assessment process. The EU Integrated Project ReProTect (6thFramework Programme) implemented an array of in vitro tests to study different building blocks of the mammalian reproductive cycle: methodological developments and results on male and female germ cells, prostate and placenta are presented.
Original languageEnglish
Pages (from-to)429 - 444
Number of pages16
JournalAnnali dell'Istituto Superiore di Sanita
Issue number4
Publication statusPublished - 2011
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

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