Intraoperative beta- detecting probe for radio-guided surgery of brain tumors

G. Baroni, F. Bellini, V. Bocci, F. Collamati, M. Cremonesi, E. De Lucia, R. Faccini, P. Ferroli, S. Fiore, F. Fioroni, C.M. Grana, E. Grassi, M. Iori, M. Marafini, I. Mattei, S. Morganti, G. Paganelli, V. Patera, A. Pepe, L. PiersantiL. Recchia, A. Russomando, A. Sarti, A. Sciubba, M. Schiariti, E. Solfaroli Camillocci, A. Versari, C. Voena

Research output: Contribution to conferencePaper

Abstract

The innovation of the radio-guided surgery exploiting β- emitters is the higher tumor-to-non-tumor ratio (TNR) allowing both a smaller radiopharmaceutical absorbed dose to detect cancerous remnants and the possibility of extending the technique also to cases with a large uptake of surrounding healthy organs, as for brain tumors. Our first study cases are meningiomas, since an appropriate β- emitting drug is already available (90Y-DOTATOC), but the goal is to apply this technique to gliomas. We verified the uptake of the radiotracer in 8/10 patients affected by meningiomas with TNR ≥ 10 and in 9/12 patients with a TNR ≥ 4 in case of gliomas. We developed prototypes of an intraoperative probe detecting β- radiation. The core of the probe is a millimetric scintillator made of para-terphenyl due to its high light yield and low density. Tests in laboratory showed that with a radiotracer activity on the tumor of 5 kBq/ml and a TNR of 10 a 0.1 ml cancerous residual can be detected in 1s. That corresponds to administer to the patient 1 MBq/kg of radiopharmaceutical, which is a dose comparable to those administered for diagnostic use. Finally we estimated with a detailed simulation the exposure of the surgeon resulted in ∼0.1 Sv/h to the whole body and ∼1 Sv/h to the hands, well below the corresponding values for established RGS with gamma radiation.
Original languageEnglish
DOIs
Publication statusPublished - 10 Mar 2016
Externally publishedYes
EventIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 - Seattle, United States
Duration: 10 Mar 2016 → …

Conference

ConferenceIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
CountryUnited States
CitySeattle
Period10/3/16 → …

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All Science Journal Classification (ASJC) codes

  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Baroni, G., Bellini, F., Bocci, V., Collamati, F., Cremonesi, M., De Lucia, E., ... Voena, C. (2016). Intraoperative beta- detecting probe for radio-guided surgery of brain tumors. Paper presented at IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014, Seattle, United States. https://doi.org/10.1109/NSSMIC.2014.7430882