Investigation of human biomarkers in exhaled breath by laser photoacoustic spectroscopy

D.C. Dumitras, G. Giubileo, A. Puiu

Research output: Contribution to conferencePaper

8 Citations (Scopus)


The paper underlines the importance of breath tests in medicine and the potential of laser techniques to measure in-vivo and in real time human biomarkers. The presence of trace amounts of gases or the metabolites of a precursor in exhaled air could be linked to kidney or liver malfunction, asthma, diabetes, cancer, ulcers or neurological disorders. The measurement of some human biomarkers (ethylene, ammonia), based on laser photoacoustic spectroscopy methods, insure very high sensitivity and selectivity. The technical characteristics of this instrument were measured to determine the detection limits (sub-ppb for ethylene). The results of ethylene release following lipid peroxidation initiated by X-ray irradiation or ingestion of radioactive compounds are presented. The possibility to extend this technique for measurement of breath ammonia levels in patients with end-stage renal disease while they are undergoing hemodialysis is discussed.
Original languageEnglish
Publication statusPublished - 2005
Externally publishedYes
EventAdvanced Laser Technologies 2004 - , Italy
Duration: 1 Jan 2005 → …


ConferenceAdvanced Laser Technologies 2004
Period1/1/05 → …


All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Dumitras, D. C., Giubileo, G., & Puiu, A. (2005). Investigation of human biomarkers in exhaled breath by laser photoacoustic spectroscopy. Paper presented at Advanced Laser Technologies 2004, Italy.