Laser based assessment of lipid peroxidation in humans

Gianfranco Giubileo

Research output: Contribution to conferencePaper

7 Citations (Scopus)

Abstract

Infrared absorption spectroscopy can be performed at very high resolution by tunable diode laser (TDL) based optical systems for any gas with well resolved absorption spectra. In a double beam setup atmospheric trace gas concentration can be measured down to ppb levels. The analysis of trace gases may have useful applications in detecting chemicals in the human breath for non invasive medical diagnostic. The capability of TDL based breath analysis was well demonstrated by monitoring ammonia and methane. In the human body the formation of free radicals does induce oxidative degradation of polyunsaturated fatty acids (lipid peroxidation) which is a damage for cells and organs in the organism. Specific volatile hydrocarbons generated as end product by lipid peroxidation (LP) can be found inside circulating blood and expired breath. TDL based analysis of those specific hydrocarbons (ethane and pentane) in the expired breath can allow a non invasive assessment of the LP extent. ©2003 Copyright SPIE - The International Society for Optical Engineering.
Original languageEnglish
DOIs
Publication statusPublished - 1998
Externally publishedYes
EventROMOPTO '97: 5th Conference on Optics - , Unknown
Duration: 1 Jan 1998 → …

Conference

ConferenceROMOPTO '97: 5th Conference on Optics
CountryUnknown
Period1/1/98 → …

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All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Applied Mathematics

Cite this

Giubileo, G. (1998). Laser based assessment of lipid peroxidation in humans. Paper presented at ROMOPTO '97: 5th Conference on Optics, Unknown. https://doi.org/10.1117/12.312823