Levodopa therapy reduces DNA damage in peripheral blood cells of patients with Parkinson's disease

T. Cornetta, S. Palma, I. Aprile, L. Padua, P. Tonali, A. Testa, R. Cozzi

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Abstract

Oxidative stress seems to play a major role in the pathogenesis of neurodegeneration. In Parkinson's disease (PD) patients, the dopaminergic neurons are subjected to oxidative stress resulting from reduced levels of antioxidant defenses such as glutathione and high amount of intracellular iron. Levodopa (LD) is widely used for the symptomatic treatment of PD, but its role in oxidative damage control is still unclear. The aim of this study was to analyze the presence of DNA damage in peripheral blood lymphocytes (PBL) of PD patients, during a washout and a controlled LD dosage and to evaluate the oxidative damage fluctuation after LD intake. The standard and the Fpg-modified version of Comet assay were applied in analyzing DNA damage in PBL from blood samples of nine PD patients and nine matched controls. Due to the limited number of patients we cannot reach definite conclusions even if our data confirm the accumulation of DNA lesions in PD patients; these lesions decrease after LD intake. © 2008 Springer Science+Business Media B.V.
Original languageEnglish
Pages (from-to)321 - 330
Number of pages10
JournalCell Biology and Toxicology
Volume25
Issue number4
DOIs
Publication statusPublished - Aug 2009
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Toxicology
  • Cell Biology
  • Health, Toxicology and Mutagenesis

Cite this

Cornetta, T., Palma, S., Aprile, I., Padua, L., Tonali, P., Testa, A., & Cozzi, R. (2009). Levodopa therapy reduces DNA damage in peripheral blood cells of patients with Parkinson's disease. Cell Biology and Toxicology, 25(4), 321 - 330. https://doi.org/10.1007/s10565-008-9086-6