Melatonin as immunompdulator in immunodeficient mice

M.Cristina Caroleo, Daniela Frasca, Giuseppe Nisticó, Gino Doria

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Melatonin, the main hormone of the pineal gland, when chronically injected into young mice or mice immuno-depressed by aging or by cyclophosphamide treatment, is able to enhance the antibody response to a T-dependent antigen. The enhancement of the antibody response is associated with increased induction of T helper cell activity and IL-2 production, as evidenced in mice immunodepressed by aging or by cyclophosphamide treatment. These observations suggest that melatonin treatment may be successfully used in the therapy of immunodepressive conditions. © 1992.
Original languageEnglish
Pages (from-to)81 - 89
Number of pages9
Issue number2
Publication statusPublished - 4 Mar 1992
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Caroleo, M. C., Frasca, D., Nisticó, G., & Doria, G. (1992). Melatonin as immunompdulator in immunodeficient mice. Immunopharmacology, 23(2), 81 - 89.