Melatonin increases antigen presentation and amplifies specific and non specific signals for T-cell proliferation

Claudio Pioli, M.Cristina Caroleo, Giuseppe Nistico', Gino Doriac

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Our preceding results have shown that melatonin administration to normal and immunodepressed mice increases significantly the antibody response. We also found that melatonin is able to restore the impaired T-helper cell activity in immunodepressed mice. The present study shows that melatonin enhances antigen presentation by splenic macrophages to T-cells. This effect is concomitant with an increase in the expression of MHC class II molecules and production of IL-1 and TNF-α. Considering the role of antigen presentation and cytokine production in the initiation of the immune response, the present findings provide evidence for relevant mechanisms that may account for the regulatory role of the pineal gland in immunoregulation. © 1993.
Original languageEnglish
Pages (from-to)463 - 468
Number of pages6
JournalInternational Journal of Immunopharmacology
Issue number4
Publication statusPublished - 1993
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology

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