Monte Carlo optimisation of a BNCT facility for treating brain gliomas at the TAPIRO reactor

Elisabetta Nava, K.W. Burn, L. Casalini, C. Petrovich, G. Rosi, M. Sarotto, R. Tinti

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Abstract

An epithermal boron neutron capture therapy facility for treating brain gliomas is currently under construction at the 5 kW fast-flux reactor TAPIRO located at ENEA, Casaccia, near Rome. In this work, the sensitivity of the results to the boron concentrations in healthy tissue and tumour is investigated and the change in beam quality on modifying the moderator thickness (within design limits) is studied. The Monte Carlo codes MCNP and MCNPX were used together with the DSA in-house variance reduction patch. Both usual free beam parameters and the in-phantom treatment planning figures-of-merit have been calculated in a realistic anthropomorphic phantom ('ADAM'). © The Author 2005. Published by Oxford University Press. All rights reserved.
Original languageEnglish
Pages (from-to)475 - 481
Number of pages7
JournalRadiation Protection Dosimetry
Volume116
Issue number1-4
DOIs
Publication statusPublished - 20 Dec 2005
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Nuclear Energy and Engineering
  • Radiation

Cite this

Nava, E., Burn, K. W., Casalini, L., Petrovich, C., Rosi, G., Sarotto, M., & Tinti, R. (2005). Monte Carlo optimisation of a BNCT facility for treating brain gliomas at the TAPIRO reactor. Radiation Protection Dosimetry, 116(1-4), 475 - 481. https://doi.org/10.1093/rpd/nci029