Muscle extracellular matrix scaffold is a multipotent environment

Paola Aulino, Alessandra Costa, Ernesto Chiaravalloti, Barbara Perniconi, Sergio Adamo, Dario Coletti, Massimo Marrell, Marco Tatullo, Laura Teodori

Research output: Contribution to journalArticle

35 Citations (Scopus)


The multipotency of scaffolds is a new concept. Skeletal muscle acellular scaffolds (MAS) implanted at the interface of Tibialis Anterior/tibial bone and masseter muscle/mandible bone in a murine model were colonized by muscle cells near the host muscle and by bone-cartilaginous tissues near the host bone, thus highlighting the importance of the environment in directing cell homing and differentiation. These results unveil the multipotency of MAS and point to the potential of this new technique as a valuable tool in musculo-skeletal tissue regeneration.
Original languageEnglish
Pages (from-to)336 - 340
Number of pages5
JournalInternational Journal of Medical Sciences
Issue number4
Publication statusPublished - 6 Apr 2015
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Aulino, P., Costa, A., Chiaravalloti, E., Perniconi, B., Adamo, S., Coletti, D., Marrell, M., Tatullo, M., & Teodori, L. (2015). Muscle extracellular matrix scaffold is a multipotent environment. International Journal of Medical Sciences, 12(4), 336 - 340.