[186gRe]Re-HEDP is a radiopharmaceutical used for pain palliation in bone metastases from various primary tumors. The negatron emitter with 〈Eβ〉 = 357 keV186gRe is suitable to irradiate cancer and inflammatory cells, but it needs labeling bis-phosphonates as vectors to reach target tissue. Paper radiochromatography was used to evaluate the radiochemical purity of [186gRe]Re-HEDP in radiopharmaceutical solution as well as in biological samples (serum and urine) from treated patients, in order to follow bone-targeting and excretion. Following the activity concentration in each sample vs. time it is effective to elaborate a bio-kinetic model of the radiopharmaceutical and to optimize administration protocols. © 2008 Springer Science+Business Media, LLC.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Inorganic Chemistry
- Nuclear Energy and Engineering
Ridone, S., Bonardi, M. L., Groppi, F., Martinotti, A., & Alfassi, Z. B. (2008). Paper radiochromatography for evaluation of radiochemical purity and stability of [. Journal of Radioanalytical and Nuclear Chemistry, 277(1), 117 - 123. https://doi.org/10.1007/s10967-008-0718-3