Paper radiochromatography for evaluation of radiochemical purity and stability of [

S. Ridone, M.L. Bonardi, F. Groppi, A. Martinotti, Z.B. Alfassi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

[186gRe]Re-HEDP is a radiopharmaceutical used for pain palliation in bone metastases from various primary tumors. The negatron emitter with 〈Eβ〉 = 357 keV186gRe is suitable to irradiate cancer and inflammatory cells, but it needs labeling bis-phosphonates as vectors to reach target tissue. Paper radiochromatography was used to evaluate the radiochemical purity of [186gRe]Re-HEDP in radiopharmaceutical solution as well as in biological samples (serum and urine) from treated patients, in order to follow bone-targeting and excretion. Following the activity concentration in each sample vs. time it is effective to elaborate a bio-kinetic model of the radiopharmaceutical and to optimize administration protocols. © 2008 Springer Science+Business Media, LLC.
Original languageEnglish
Pages (from-to)117 - 123
Number of pages7
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume277
Issue number1
DOIs
Publication statusPublished - Jul 2008
Externally publishedYes

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Inorganic Chemistry
  • Nuclear Energy and Engineering

Cite this