Plant-based vaccine delivery strategies

Chiara Lico, Carla Marusic, Floriana Capuano, Giampaolo Buriani, Eugenio Benvenuto, Selene Baschieri

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

5 Citations (Scopus)

Abstract

Subunit vaccine formulations were prepared in the near past by purifying antigenic components known to activate protective immune responses directly from the pathogen. Nowadays, thanks to the development of high performance gene engineering and biochemical procedures, subunit vaccines commence to be formulated with recombinant versions of protective antigens. These molecules can be synthesized using heterologous hosts such as bacteria, yeast, insect and mammalian cells. To this aim, the alternative use of plants is growing out of advances in methods for foreign gene expression. Plants represent an opportunity in the field of vaccine technology in that this expression system ensures rapidity, low costs, easy scaling up and intrinsic bio-safety of the final product. Nonetheless, the exploitation of plants only as mere biofactories of antigens thwarts many of their potentialities. After a short introduction designed to initiate the reader to the most commonly used methods to engineer plant biofactories, the chapter will focus on how plants can be used by themselves as vaccines or as source of recombinant antigens with immunologic added value.
Original languageEnglish
Title of host publicationInnovation in Vaccinology: From Design, Through to Delivery and Testing
PublisherSpringer Netherlands
ISBN (Electronic)9789400745438
ISBN (Print)9400745427
DOIs
Publication statusPublished - 1 Nov 2012
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lico, C., Marusic, C., Capuano, F., Buriani, G., Benvenuto, E., & Baschieri, S. (2012). Plant-based vaccine delivery strategies. In Innovation in Vaccinology: From Design, Through to Delivery and Testing Springer Netherlands. https://doi.org/10.1007/978-94-007-4543-8_8