Plant-derived vaccines and other therapeutics produced in contained systems

Rosella Franconi, Olivia Costantina Demurtas, Silvia Massa

Research output: Contribution to journalReview article

52 Citations (Scopus)


The use of contained plant systems for the production of biopharmaceuticals represents a powerful alternative to current methods, combining the benefits of whole-plant systems and cell cultures. In vitro contained production systems include plant cell suspensions, hairy root cultures, novel plants grown in contained conditions and microalgae. These systems show intrinsic advantages, such as control over growth conditions, production in compliance with good manufacturing practice and avoidance of political resistance to the release of genetically modified field crops. At present, one of the two plant-produced vaccine-related products that have gone all the way through production and regulatory hurdles derives from tobacco cell suspensions, and the second is a human therapeutic enzyme, which is expected to reach commercial development soon and derives from carrot suspension cells. In the future, several other products from contained systems are expected to reach the clinical trial stage. © 2010 Expert Reviews Ltd.
Original languageEnglish
Pages (from-to)877 - 892
Number of pages16
JournalExpert Review of Vaccines
Issue number8
Publication statusPublished - 2010
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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