The adducts produced in vitro by the reactive metabolites of [14C]-chloroform with total phospholipids (PLs) of freshly isolated hepatocytes have been characterized. The radical metabolite formed several adducts with all the major PL classes. These adducts seemed very likely to result from the unspecific attack of the radical on the PL fatty acyl chains. [14C]-Chloroform-derived phosgene caused the formation of a single PL adduct characterized by a ratio 14C:P of 1:4. This adduct was tentatively identified as an adduct of phosgene with two molecules of cardiolipin. © 1996 John Wiley & Sons, Inc.
|Pages (from-to)||21 - 25|
|Number of pages||5|
|Journal||Journal of Biochemical Toxicology|
|Publication status||Published - 1996|
All Science Journal Classification (ASJC) codes
Guastadisegni, C., Balduzzi, M., & Vittozzi, L. (1996). Preliminary characterization of phospholipid adducts formed by [. Journal of Biochemical Toxicology, 11(1), 21 - 25. https://doi.org/10.1002/(SICI)1522-7146(1996)11:1<21::AID-JBT3>3.0.CO;2-X