Preparation of albumin-ferrite superparamagnetic nanoparticles using reverse micelles

Mariangela Bellusci, Aurelio La Barbera, Luca Seralessandri, Franco Padella, Antonella Piozzi, Francesca Varsanoa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Micellar systems are widely applied as reactors to encapsulate inorganic nanoparticles in polymeric materials. However, only low inorganic contents and microscale dimensions are often achieved. Results: The adsorption of albumin protein on ferrite nanoparticles permits to increase the stability of inorganic dispersions in water by inhibiting particle flocculation. Subsequent glutaraldehyde addition induces protein crosslinking and ferrite entrapment. Polymer-ferrite composite nanoparticles were obtained in this way. The magnetic albumin nanoparticles (25 nm mean diameter) obtained contain about 40 wt% of ferrite and show superparamagnetic behaviour. The composite powder was successfully functionalized with a model drug and the biological activity was evaluated. Conclusion: Using a reverse micelle approach, ferrite-albumin composite nanoparticles with a high inorganic content were obtained. The method permits the formulation of biocompatible magnetic particles of nanoscale dimensions. The exhibited superparamagnetic behaviour permits to hypothesize an application of the powder composite as a carrier in biomedical technologies. © 2009 Society of Chemical Industry.
Original languageEnglish
Pages (from-to)1142 - 1147
Number of pages6
JournalPolymer International
Volume58
Issue number10
DOIs
Publication statusPublished - 1 Oct 2009
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Polymers and Plastics

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