Breast cancer has a variable clinical presentation. Metastatic disease ranges from limited bone involvement to multiorgan spread. The liver is frequently affected in the course of metastatic diffusion. In this chapter is reported our experience with 90Y radioembolisation (RE) in the treatment of patients affected by metastatic breast cancer. We also provide information regarding the application of new angiographic techniques (ex.Dyna CT). The indications for 90Y RE are inoperable and chemorefractory hepatic metastasis, acceptable performance status (ECOG), sufficient residual liver function and no significant hepato-pulmonary shunts. Most relevant complications are post procedural hepatic failure, gastritis and gastroduodenal ulcers, caused by non targeted 90Y implantation. The patients treated with RE have a better prognosis with prolongation of survival and progression free survival. 90Y RE is an effective and safe procedure, well tolerated especially in those patients with preserved liver function. It can be performed either as salvage procedure or in combination with chemoteraphy.
|Title of host publication||Microspheres: Technologies, Applications and Role in Drug Delivery Systems|
|Publisher||Nova Science Publishers, Inc.|
|Publication status||Published - 1 Jan 2014|
All Science Journal Classification (ASJC) codes
- Materials Science(all)
Cianni, R., Pelle, G., & D'Arienzo, M. (2014). Radiembolization with 90Y microspheres in the treatment of liver metastatic disease from breast cancer. In Microspheres: Technologies, Applications and Role in Drug Delivery Systems Nova Science Publishers, Inc..