Recent advances in understanding the role of adipocytokines during non-alcoholic fatty liver disease pathogenesis and their link with hepatokines

Nadia Panera, Claudia Della Corte, Annalisa Crudele, Laura Stronati, Valerio Nobili, Anna Alisi

Research output: Contribution to journalReview article

9 Citations (Scopus)


Non-alcoholic fatty liver disease (NAFLD) is currently considered the main cause of chronic liver disease worldwide. Mechanisms leading to the development and progression of this disease are topics of great interest for researchers and clinicians. The current multi-hit hypothesis has thrown the crosstalk between liver and adipose tissue into sharp focus. It is well known that adipose tissue produces circulating factors, known as adipocytokines, which exert several effects on liver cells, promoting the onset of NAFLD and its progression to non-alcoholic steatohepatitis in obese subjects. In a similar way, hepatocytes may also respond to obesogenic stimuli by producing and releasing hepatokines into the circulation. Here, the authors provide an overview of recent advances in our understanding of the role of the most relevant adipocytokines and hepatokines in NAFLD pathogenesis, highlighting their possible molecular and functional interactions.
Original languageEnglish
Pages (from-to)393 - 403
Number of pages11
JournalExpert Review of Gastroenterology and Hepatology
Issue number3
Publication statusPublished - 3 Mar 2016
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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