Resveratrol affects DNA damage induced by ionizing radiation in human lymphocytes in vitro

Emiliano Basso, Giulia Regazzo, Mario Fiore, Valentina Palma, Gianandrea Traversi, Antonella Testa, Francesca Degrassi, Renata Cozzi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Resveratrol (3,4′,5-trihydroxystilbene; RSV) acts on cancer cells in several ways, inducing cell cycle delay and apoptotic death, and enhancing ionizing radiation (IR)-mediated responses. However, fewer studies have examined RSV effects on normal cells. We have treated human lymphocytes in vitro with RSV, either alone or combined with IR, to evaluate its potential use as a radioprotector. We measured the effects of RSV on induction of DNA damage, repair kinetics, and modulation of histone deacetylase activity.
Original languageEnglish
Pages (from-to)40 - 46
Number of pages7
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume806
DOIs
Publication statusPublished - 1 Aug 2016
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Health, Toxicology and Mutagenesis

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