Si-based nanoparticles: A biocompatibility study

I. Rivolta, B. Lettiero, A. Panariti, R. D'Amato, V. Maurice, M. Falconieri, N. Herlein, E. Borsella, G. Miserocchi

Research output: Contribution to conferencePaper

Abstract

Exposure to silicon nanoparticles (Si-NPs) may occur in professional working conditions or for people undergoing a diagnostic screening test. Despite the fact that silicon is known as a non-toxic material, in the first case the risk is mostly related to the inhalation of nanoparticles, thus the most likely route of entry is across the lung alveolar epithelium. In the case of diagnostic imaging, nanoparticles are usually injected intravenously and Si-NPs could impact on the endothelial wall. In our study we investigated the interaction between selected Si-based NPs and an epithelial lung cell line. Our data showed that, despite the overall silicon biocompatibility, however accurate studies of the potential toxicity induced by the nanostructure and engineered surface characteristics need to be accurately investigated before Si nanoparticles can be safely used for in vivo applications as bio-imaging, cell staining and drug delivery. © 2010 American Institute of Physics.
Original languageEnglish
DOIs
Publication statusPublished - 2010
Externally publishedYes
EventBONSAI Project Symposium: Breakthroughs in Nanoparticles for Bio-Imaging - , Italy
Duration: 1 Jan 2010 → …

Conference

ConferenceBONSAI Project Symposium: Breakthroughs in Nanoparticles for Bio-Imaging
CountryItaly
Period1/1/10 → …

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All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

Rivolta, I., Lettiero, B., Panariti, A., D'Amato, R., Maurice, V., Falconieri, M., ... Miserocchi, G. (2010). Si-based nanoparticles: A biocompatibility study. Paper presented at BONSAI Project Symposium: Breakthroughs in Nanoparticles for Bio-Imaging, Italy. https://doi.org/10.1063/1.3505090