Spectral analysis of induced fluorescence in thyroid tissue

Gianfranco Giubileo, Francesco Colao, Paolo Rocchini, Giuseppe Panzironi

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Abstract

Recently the application of optical techniques to the detection of cancer, has received an increasing interest from physicians and biophysicists, because of its peculiarities such as non-invasively, very fast response, easy-to-use apparatus. Useful applications of this technique have already been demonstrated for the in-vivo locating of small size tumour areas by endoscopic diagnose of fluorescent tissue or by direct sensing of the patient skin. In view of its specific advantages, fluorescence analysis of tissue samples coming from biopsies are welcome to replace standard methods in the istological analysis, resulting in minimisation of process time, and giving error free responses providing a really objective analysis. In this paper thyroid samples have been analysed by fluorescent technique and characterisation of the spectral response has been performed by studying both emission and excitation fluorescence spectra. The measurements have been performed by using a double monochromator spectrofluorometer. The nature of the medium containing the tissue sample has resulted to be of great importance in eliminating spurious effects not related to the sample itself. Observations fulfilled on a number of samples will be reported and comparison between healthy tissue and tumour tissue will be discussed.
Original languageEnglish
Pages (from-to)132 - 139
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4252
DOIs
Publication statusPublished - 2001
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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