Sperm chromatin structure and male fertility: Biological and clinical aspects

Juris Erenpreiss, M. Spano, J. Erenpreisa, M. Bungum, A. Giwercman

Research output: Contribution to journalReview article

202 Citations (Scopus)


Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed. © 2006, Asian Journal of Andrology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences. All rights reserved.
Original languageEnglish
Pages (from-to)11 - 29
Number of pages19
JournalAsian Journal of Andrology
Issue number1
Publication statusPublished - Jan 2006
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Urology

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