Ultrasound-guided percutaneous laser ablation of liver tissue in a rabbit model

C.M. Pacella, Z. Rossi, G. Bizzarri, E. Papini, V. Marinozzi, D. Paliotta, P. Castaldo, V. Ziparo, F. Garosi, M. Cinti, F. Muzzi

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19 Citations (Scopus)


The present report evaluates the efficacy and safety of percutaneous interstitial laser tissue ablation of the liver in nine New Zealand rabbits. A Nd: YAG laser was coupled to a quartz fibreoptic guide (600 μm) with a flat tip. The fibre and a thermocouple were placed in the lumen of two Chiba needles (18G) and these were inserted into the liver 10 mm apart under ultrasound guidance. The laser was fired for 5 min at 1, 3 and 5 W power, respectively, in three groups of rabbits. There were no acute complications and all the rabbits except one survived until the established time of sacrifice. The procedure induced a cavity surrounded by a zone (about 10 mm) of coagulative necrosis. After 2 weeks a strong peripheral inflammatory response was evident and after 4 weeks a capsule of connective tissue enclosed the lesions. Our study seems to offer a safe and rapid technique producing a "guaranteed kill radius" for the treatment of small hepatic neoplasms. © 1993 Springer-Verlag.
Original languageEnglish
Pages (from-to)26 - 32
Number of pages7
JournalEuropean Radiology
Issue number1
Publication statusPublished - Jan 1993
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Pacella, C. M., Rossi, Z., Bizzarri, G., Papini, E., Marinozzi, V., Paliotta, D., ... Muzzi, F. (1993). Ultrasound-guided percutaneous laser ablation of liver tissue in a rabbit model. European Radiology, 3(1), 26 - 32. https://doi.org/10.1007/BF00173518