Use of hematopoetic cytokines to accelerate the recovery of the immune system in irradiated mice

D. Frasca, F. Guidi, M. Arbitrio, C. Pioli, G. Leter, M. Spano, G. Doria

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Abstract

In our previous studies aimed at designing appropriate strategies to accelerate recovery of the immune system after irradiation, we found that the hematopoietic cytokine recombinant murine (rmu) interleukin (IL)-3 was able to induce differentiation and growth of thymocytes and splenic T and B lymphocytes in mice exposed to x-rays (200-500 cGy). The recovery, however, was complete at 7 days only after a dose of 200 cGy, whereas 2, 3, and 4 weeks were necessary to achieve full recovery after 300, 400, and 500 cGy, respectively. These studies were extended to investigate the effects of another hematopoietic cytokine, recombinant human (rhu) IL-11, a bone marrow stromal-derived cytokine, administered together with IL-3 to irradiated mice. The synergistic effect of the two cytokines was evident when relatively small doses of rhu IL-11 were injected with an optimal dose of rmu IL-3.
Original languageEnglish
Pages (from-to)1167 - 1171
Number of pages5
JournalExperimental Hematology
Volume25
Issue number11
Publication statusPublished - 1997
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

Cite this

Frasca, D., Guidi, F., Arbitrio, M., Pioli, C., Leter, G., Spano, M., & Doria, G. (1997). Use of hematopoetic cytokines to accelerate the recovery of the immune system in irradiated mice. Experimental Hematology, 25(11), 1167 - 1171.